According to the official website of CVS Pharmacy, the retail chain is typically open on Memorial Day. However, it is advisable to check with your local CVS Pharmacy store to confirm their operating hours for the holiday. Memorial Day is a federal holiday observed annually on the last Monday of May in honor of the men and women who died while serving in the U.S. military. As such, many businesses may have modified hours or be closed in observance of the holiday. It is always recommended to plan ahead and confirm the operating hours of any business you intend to visit on Memorial Day to avoid any inconvenience.